Centella

Products containing Centella asiatica extract are available in a variety of pharmaceutical forms for internal and external use. These include:

• Capsules and tablets: for oral administration, with a role in supporting cognitive function, circulation, and skin health.
• Liquid extract or tincture: used for phytotherapeutic purposes.
• Creams, lotions, ointments, and balms: for topical use, with dermatological, anti-inflammatory, and regenerative indications.
• Serums, patches, and multifunctional cosmetic products: intended for skin care routines, especially for sensitive or acne-prone skin.

Manufacturers - Swanson, Now Foods, COSRX, Herbagen, Purito Centella, etc.

Centella is indicated in the following therapeutic and prophylactic contexts:

• Supporting cognitive function and mental health: standardized Centella asiatica extract can help improve memory, attention, and concentration
• Reducing symptoms of anxiety and stress: through its adaptogenic action, Centella asiatica can modulate the physiological response to stress and reduce cortisol levels.
• Improved peripheral circulation: used to reduce edema, improve chronic venous insufficiency, and alleviate symptoms associated with varicose veins.
• Accelerating skin regeneration processes: promotes collagen synthesis, healing of lesions and reduction of stretch marks, scars or irritations.
• Combating skin inflammation: effective in the treatment of dermatitis, minor burns, acne, or eczema.

The dosage depends on the form of administration and the concentration of the extract:

• For internal use: it is recommended to take one capsule per day, with food and water, preferably in the morning.
• For external use: apply the cream or ointment locally 1-2 times a day to clean skin, in a thin layer, massaging gently until absorbed.

It is essential to follow the instructions on the product label and consult a specialist before starting treatment.

The use of Centella asiatica-based products is contraindicated in the following situations:

• Pregnancy and breastfeeding – due to lack of safety data
• Under 18 years of age – without a doctor's recommendation
• History of skin cancer 
• Liver disease (hepatitis, cirrhosis) – the plant may affect liver metabolism
• Severe skin allergies – topical application may trigger allergic reactions

Although it is well tolerated by most patients, Centella asiatica requires certain precautions:

• Preliminary skin testing is required for locally applied products 
• For oral supplements, it is advisable to avoid combining with other hepatotoxic substances
• Patients with diabetes, high cholesterol, or thyroid dysfunction should seek medical advice
• Use in the preoperative period should be discontinued at least two weeks before surgery due to the risk of interaction with anesthetics and coagulopathies

Adverse effects reported in the literature are rare and generally mild to moderate in intensity:

• Oral administration: nausea, headache, dizziness, gastric discomfort, drowsiness.
• Topical application: local irritation, erythema, pruritus, or burning sensation on the skin.

Centella may interact with the following classes of drugs:

• Sedatives, anxiolytics: potentiation of the sedative effect
• Hepatotoxic (paracetamol, isoniazid, methotrexate): possible increase in liver toxicity
• Diuretics: risk of electrolyte imbalance

No relevant interactions with food are known. 

Data on overdose with Centella asiatica are limited. Possible symptoms in case of overdose may include:

• Excessive drowsiness
• Gastrointestinal disorders (nausea, diarrhea)
• Severe headache
• Liver damage (in case of prolonged high doses)

In case of accidental overdose, it is recommended to contact a specialized medical service immediately.

To maintain their stability, products containing Centella asiatica should be stored according to the following recommendations:

• Optimal temperature: below 25°C
• Dry location, away from direct light and moisture
• Keep out of reach of children
• Do not freeze or expose to excessive heat

After opening topical containers, it is recommended to use within the period specified on the packaging (usually 3-6 months).

• WebMD, Gotu kola
• Healthline, Gotu kola
• PubMed, Gotu Kola (Centella asiatica): Nutritional Properties and Potential Health Benefits
• PubMed, Pharmacological study of Centella asiatica: A potential medicinal plant