In&out 5.5 Biotic Barrier Action. Enriched with pre- and postbiotics, it targets the most external and often overlooked part of the skin: the microbiome. It also contains moisturizing active ingredients with high antioxidant power. Eco-friendly packaging. Maintains, improves and strengthens the epidermal barrier. Ceramide precursors. Hemp seed oil. Niacinamide. Shea butter. Squalane. Maintains, improves and strengthens the microbiome. Pre and postbiotics. Antioxidant power. Hydroxytyrosol. Ferulic acid. Vitamin E. Hydration and repair. Aloe vera. Panthenol. Hyaluronic acid. Who is 5punto5 Biotic Barrier indicated for? Essential in any cosmetic routine. Irritated skin with a feeling of tightness and dryness. Complementary to the use of retinoids and hydroxy acids. Essential care in treatment with oral retinoids. Pre and post dermatological procedures. How to use. Daily use, both day and night