Paracetamol
Description Paracetamol
The information in the FAQ section was created by the Liki24.co.uk team and is based on the official manufacturer's manual
Paracetamol or acetaminophen is a medicine containing a derivative of para-aminophenol with analgesic (pain-relieving) and antipyretic (fever-reducing) effects, similar to those of non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen, etc.). The analgesic and antipyretic effect is maximum within 1-3 hours and lasts for 3-4 hours after administration.
Forms of release
Paracetamol is available in several forms:
- Paracetamol 500 mg, Therapy
- Paracetamol 500 mg, tablets, Labormed
- Paracetamol Helcor, 500 mg, tablets, Helcor
- Paracetamol Zentiva 500 mg, tablets, Zentiva
- Paracetamol 125 mg, suppositories, Antibiotice
- Paracetamol syrup, 120 mg/5 ml, 100 ml, Tis Farmaceutic
- Paracetamol Slavia, 500 mg, tablets
- Parasinus, Gsk
- Paracetamol Penta – Parasinus Penta, Gsk
Paracetamol can be administered to adults and adolescents over 12 years of age in the form of tablets (pills) or effervescent tablets, suppositories or in an injectable form (paracetamol for injection). In children under 6 years of age, paracetamol is administered in the form of a suspension (syrup) or suppositories.
There are also many medicines that enhance the effect of paracetamol by combining several molecules. Paracetamol is available in combination with tramadol (a weak opioid), phenylephrine (a nasal decongestant, useful in reducing the symptoms caused by colds and flu), or caffeine.
Indications for use
What is paracetamol good for? Paracetamol is indicated for the treatment of mild to moderate pain in various locations: headaches, migraines, joint and rheumatic pain, muscle pain, back pain, post-traumatic pain, toothache, and menstrual pain. For colds and flu, paracetamol relieves muscle pain and reduces fever caused by viral infections.
Dosage and administration
What is the dose of paracetamol and how often should paracetamol be taken: For adults and adolescents over 12 years of age, the recommended dose of paracetamol is 1-2 tablets (500-1000 mg), and if necessary, the dose may be repeated after 4-6 hours. Paracetamol should not be taken at intervals of less than 4 hours.
The maximum recommended dose for adults is 4 g of paracetamol per day (8 tablets/day), and the recommended single dose is 1 g (2 tablets administered once).
For children aged 6-12 years, the recommended dose of paracetamol is ½-1 tablet (250-500 mg) every 4 hours. The maximum recommended dose is 60 mg/kg, calculated according to the child's weight. Do not administer at intervals of less than 4 hours and do not exceed 4 doses in 24 hours.
For children under 6 years and over 3 months, the maximum recommended daily dose is 60 mg paracetamol/kg, divided into doses of 10-15 mg/kg in 24 hours. The dose can be more easily determined by following the instructions on the package leaflet.
Contraindications
There are also some contraindications for paracetamol. Paracetamol is contraindicated in patients who have had hypersensitivity or allergic reactions to paracetamol. Also, do not use paracetamol if you have liver failure. Contraindications for paracetamol are also described in patients with glucose-6-phosphate dehydrogenase deficiency.
Interactions with other medicines and food
It is not recommended to combine paracetamol with other medicines containing paracetamol. Also, people undergoing anticoagulant therapy require INR monitoring when taking higher doses of paracetamol over a longer period (daily, for a week, 2 g per day), as paracetamol increases the effect of these medicines.
Side effects
In general, side effects are rare with paracetamol at the recommended doses and for short periods of time. Hypersensitivity reactions, asymptomatic thrombocytopenia (decrease in the number of platelets in the blood), bleeding or haematomas, transient skin rash, paraesthesia, pruritus, adverse effects in the gastrointestinal tract, in the renal tract (renal colic, renal failure) may occur. Prolonged use may lead to liver damage, with an increase in prothrombin time (INR), serum bilirubin, LDH and transaminases (TGO, TGP).
Overdose
Follow the recommended doses and do not exceed the maximum dose of paracetamol indicated on the packaging. Overdose may cause nausea, vomiting, loss of appetite, profuse sweating, etc. in the first 24 hours. Acute ingestion of an overdose may be fatal. Seek medical assistance immediately in case of overdose.
Storage
Store at room temperature, away from moisture and heat.
List of references
FAQ
Does paracetamol affect your ability to drive?
Can I take Paracetamol for menstrual pain?
Can I take Paracetamol for back pain?
Can I take Paracetamol for headaches?
Can I take Paracetamol at the same time as non-steroidal anti-inflammatory drugs?
Can I take Paracetamol and Aspirin at the same time?
Can I take paracetamol and antibiotics at the same time?
Aspirin or paracetamol for a cold?
Can I take paracetamol for muscle fever?
Nurofen or paracetamol?
Can I take paracetamol during pregnancy?
Can I take paracetamol while breastfeeding?
Can I combine paracetamol with alcohol?
What are the long-term effects of chronic paracetamol use?
Does paracetamol stop menstruation?
Is paracetamol an antibiotic?
Features
ATC code 1 | N02BE01 |