- for mild to moderate pain, such as headache (including migraine) and toothache;
- for primary dysmenorrhea;
- for fever.

Do not use:
- if you are hypersensitive to ibuprofen or any of the excipients;
- if you have a history of hypersensitivity reactions (e.g. bronchial asthma, rhinitis, urticaria or angioedema) to acetylsalicylic acid or other NSAIDs;
- if you have a history of gastrointestinal bleeding or perforation related to previous NSAID therapy;
- if you have an active gastroduodenal ulcer or active bleeding, or a history of recurrent gastroduodenal ulcer or recurrent bleeding;
- if you have severe liver or kidney failure;
- if you have severe heart failure (NYHA class IV);
- if you are in the last trimester of pregnancy;
- if you have significant dehydration (caused by vomiting, diarrhea or insufficient fluid intake);
- if you have cerebrovascular hemorrhage or other active bleeding;
- if you have hematopoiesis disorders.

Before using Ibuprofen Ibuprofen Arena, talk to your doctor or pharmacist.

Pregnancy, breastfeeding and fertility:
Inhibition of prostaglandin synthesis may have a negative effect on pregnancy and embryonic or fetal development.
Studies show that using these substances early in pregnancy can increase the risk of miscarriage, heart defects, and gastroschisis.
The risk of cardiovascular malformations may increase from less than 1% to approximately 1.5%, depending on the dose and duration of treatment.
During the first and second trimesters of pregnancy, ibuprofen should not be used unless absolutely necessary.
In this case, it is recommended to use the lowest dose for the shortest period of time.
Ibuprofen is excreted in breast milk, but at therapeutic doses and in short-term treatments, the risk to the infant is considered low.
In the case of long-term treatments, it is recommended to discontinue breastfeeding.
The use of ibuprofen may affect fertility and is not recommended for women trying to get pregnant.
It is recommended to interrupt treatment in women who have difficulty conceiving or who are being investigated for infertility.

Driving and using machines:
In general, ibuprofen does not affect the ability to drive or use machines.
However, at high doses or in individual cases, side effects such as fatigue, drowsiness, vertigo or visual disturbances may occur, which may influence this capacity.
These effects may be more pronounced in the case of alcohol consumption.

This medicine is intended for short-term use, for a maximum of 7 days.
If symptoms persist or worsen, it is necessary to consult a doctor.
For adults, adolescents and children over 12 years of age, the recommended initial dose is 400 mg ibuprofen (one capsule), administered at intervals of 4–6 hours.
If pain or fever does not improve, 400 mg can be continued, without exceeding the maximum dose of 1200 mg (3 capsules) in 24 hours.
The capsules are swallowed whole, with a glass of water, preferably after a meal.
It is not recommended for use in children under 12 years of age.
In elderly patients, dose adjustment is not necessary, but if there are kidney or liver problems, the dose should be established individually.

Each capsule contains 400 mg ibuprofen.
Excipient with known effect: lactose monohydrate 88.60 mg.
List of excipients
Capsule contents:
Lactose monohydrate, corn starch, talc, magnesium stearate, colloidal anhydrous silica.
Capsule:
Cover:
Silicon dioxide, sodium lauryl sulfate, glacial acetic acid, glycerol, titanium dioxide (E 171), erythrosine (E 127), red iron oxide (E 172), gelatin.
Body:
Silicon dioxide, sodium lauryl sulfate, glacial acetic acid, glycerol, titanium dioxide (E 171), gelatin.

Warning:
Read all of this leaflet carefully and completely before you start using this medicine because it contains important information for you.

10 capsules