Urifast

Both products are available in the form of sachets containing soluble oral powder. Each box contains 14 sachets, designed for daily administration, dissolved in 100 ml of cold or room temperature water. The sachet form allows for accurate dosing, rapid absorption, and increased patient compliance.

Urifast is indicated for supporting urinary tract health, particularly in the prevention of recurrent urinary tract infections, through its anti-adhesive effect on uropathogenic bacteria, particularly Escherichia coli. It is useful in people prone to post-coital cystitis and during convalescence after antibiotic treatment.

Urifast Flora has extended indications, including the management of urinary tract infections and vaginal flora imbalances. Due to its probiotic content, it is particularly valuable in restoring the urogenital microbiota affected by antimicrobial treatments, hormonal imbalances, excessive hygiene, or the use of intravaginal devices.

For both products, the standard regimen recommends taking one sachet per day, dissolved in cold water. It is preferable to take it between meals, ideally at the same time each day, to maintain a constant level of active substances.

If Urifast Flora is taken concomitantly with antibiotic treatment, an interval of at least 2 hours between the two products is recommended.

Contraindications include known hypersensitivity to any of the product's ingredients.

Urifast should also be avoided during pregnancy, breastfeeding, or in children unless specifically indicated by a doctor.

Urifast can be used in 14-day courses, repeated as needed, according to the specialist's recommendation.

Special attention should be paid to the combination of Urifast Flora with oral antibiotics—timing of administration is essential to protect the viability of probiotic strains.

The products are generally well tolerated. In rare cases, mild gastrointestinal disorders such as bloating, nausea, or abdominal discomfort may occur. Allergic reactions are rare and are mainly related to hypersensitivity to cranberry or excipients.

Excessive administration of D-mannose may, in exceptional cases, cause mild osmotic diarrhea.

D-mannose is rapidly absorbed and excreted in the urine without significant metabolism, which limits the risk of drug interactions.

However, Exocyan (cranberry extract) may interact with anticoagulant drugs (e.g., warfarin), with a risk of increased clotting time.

No significant cases of overdose with D-mannose or cranberry extract have been reported. However, high doses of D-mannose may cause mild digestive disorders. In the case of Urifast Flora, excessive intake of probiotics could cause a temporary intestinal imbalance, especially in immunocompromised individuals.

In any case, administration should be discontinued and medical advice sought if symptoms persist.

Both products should be stored in their original packaging, away from moisture, at temperatures below 25°C. Refrigeration is not recommended, but exposure to excessive heat or direct sunlight should be avoided to maintain the stability of the lactic bacteria and the integrity of the plant extracts. Once a sachet has been opened, the contents should be consumed immediately.

• WebMD, D-mannose
• PubMed, Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits
• MDPI, Molecular mechanisms and therapeutic potential of cranberry, D-mannose, and flavonoids against infectious diseases: The example of urinary tract infections
• Healthline, Cranberries: nutritional aspects and health benefits