Each 0.5 ml pipette contains:
Active substances:
Fipronil.…………………………………………………………………….50.00 mg
(S)-methoprene..……………………………………………………………..60.00 mg

• In cats:
  For the treatment and prevention of flea infestations, alone or associated with ticks and/or biting lice:
  - Flea (Ctenocephalides spp.) elimination. Insecticidal efficacy against new infestations by
  Adult fleas persist for 4 weeks. Prevention of flea multiplication by inhibiting the development of
  eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas
  for six weeks after application.
  - Elimination of ticks (Ixodes spp., Dermacentor spp., Rhipicephalus sanguineus). The medication
  Veterinarian has an acaricidal efficacy that persists for up to 2 weeks against ticks (based on data)
  experimental).
  - Elimination of biting lice (Felicola subrostratus).
  The veterinary medicinal product can be used as part of a treatment strategy for the control of dermatitis.
  Flea Allergy (FA).

• In ferrets:
  - For the treatment and prevention of flea infestations, alone or associated with ticks.
  - Flea (Ctenocephalides spp.) elimination. Insecticidal efficacy against new infestations by
  adult fleas persist for 4 weeks.
  - Prevention of flea multiplication by inhibiting the development of eggs (ovicidal activity), larvae, and
  pupae (larvicidal activity) originating from eggs laid by adult fleas for four weeks after the
  application.
  - Elimination of ticks (Ixodes ricinus). The veterinary medicinal product has acaricidal efficacy.
  persistent for 4 weeks against ticks (based on experimental data).

Solution for spot-on application.
Cats:
One 0.5 ml pipette per cat, corresponding to the minimum recommended dose of 5 mg/kg of fipronil and 6 mg/kg
of (S)-methoprene.
A monthly application is recommended when there is a high risk of reinfestation, and/or if the cat is allergic to the
flea bites.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Ferrets:
One 0.5 mL pipette per ferret.
The minimum interval between applications is 2 weeks.

Overdosage (symptoms, emergency measures, antidotes), if necessary:

Cats:
No adverse reactions were observed in safety studies of the target animals conducted in cats and
kittens 8 weeks of age and older and weighing approximately 1 kg, treated once a month to five times the
Recommended dose for 6 consecutive months. The risk of experiencing adverse reactions (see section 4.6)
However, it can still increase when overdosed. Itching may occur after application.
Ferrets:
No adverse reactions have been observed in ferrets 6 months of age and older, subject to safety studies.
and treated once every 2 weeks for four treatments, at five times the recommended dose.

Use during pregnancy, breastfeeding or egg laying:

Cats:
The veterinary medicine can be used during pregnancy.
For treatment during breastfeeding.
Ferrets:
Laboratory studies conducted on cats have shown no evidence of teratogenic or toxic effects.
fetus or toxic to the mother. Therefore, any application in pregnant ferrets must be carried out in accordance with
with the benefit/risk assessment carried out by the responsible veterinarian.

Pharmacological properties
The veterinary medicinal product is an insecticidal and acaricidal solution for topical use containing a combination of
an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-
methoprene.
Pharmacotherapeutic group: topical ectoparasiticides QP53

• Hold the pipette in a vertical position.
• Tap the narrow part of the pipette to ensure that the contents remain inside the main body of the pipette.
• Detach the tip.
• Part the animal's fur at the base of the neck in front of the shoulder blades until the skin is visible.
• Place the tip of the pipette on the skin and squeeze the pipette several times until its contents are completely emptied directly onto the skin at a single point.
• When applying the veterinary medicine to the skin, avoid excessively wetting the coat, as the treated area may remain wet or greasy after application.
• If this effect occurs, it will disappear within 24 hours of application.

The potential toxicity of the veterinary medicinal product in kittens less than 8 weeks of age that are in contact
The use of a treated cat is not documented. In this case, special care must be taken. It is important to ensure that
The veterinary medicine should be applied to dry skin, in an area where the animal cannot lick it, and ensure
that the animals do not lick each other after treatment.

No information is available on the effect of bathing or shampooing on the effectiveness of the medication.
veterinarian for cats and ferrets. However, based on the information available on dogs bathed with shampoo
Starting 2 days after application of the veterinary medicine, bathing the animals is not recommended.
within two days of applying the veterinary medicinal product.
Ticks may attach individually. For this reason, transmission cannot be completely ruled out.
infectious diseases if conditions are unfavorable.

For optimal control of flea and lice infestation in a multi-animal household, all cats and
Dogs should be treated simultaneously with a suitable veterinary medicine.
Pet fleas often infest the animal's basket, bedding, and regular resting areas.
such as carpets and soft furnishings that should be treated in case of massive infestation and at the beginning of the
Control measures, using a suitable insecticide and vacuuming regularly.

Do not apply the veterinary medicine to wounds or broken skin.

Avoid contact with the animal's eyes. In case of accidental contact with the eyes, rinse immediately with water.
abundant water.

Specific precautions to be taken by the person administering the veterinary medicinal product to animals
This veterinary medicinal product may cause eye, skin, and mucous membrane irritation. Therefore, you should
Avoid contact of the veterinary medicine with the mouth, skin and eyes.

Animals or people with known hypersensitivity to insecticides or alcohol should avoid contact
with this veterinary medicinal product. Avoid contact of the contents with your fingers. If this occurs, wash your hands.
Wash your hands with soap and water.

After accidental eye exposure, rinse the eye thoroughly with clean water. If eye irritation persists
If symptoms persist, seek medical attention immediately and show the package insert or label to the doctor.
Wash your hands with soap and water after applying the veterinary medicine.
Treated animals should not be touched until the application site is dry, and should not be allowed to
Children should not play with treated animals until the application site is dry. Therefore, it is recommended not to treat them.
the animals during the day, but rather at dusk, and that these recently treated animals do not sleep
with the owners, especially with the children.

Do not smoke, drink or eat during application.
Animals or people with known hypersensitivity to fipronil or to the excipients (see section 6.1) should
Avoid all contact with the veterinary medicine.

Adverse reactions (frequency and severity):
Very rare adverse reactions reported after use include: skin reactions
transient effects at the application site (bruising, local hair loss, itching, redness), as well as itching
general or hair loss.

Following its use, excessive salivation and reversible nervous signs (increased salivation) have been observed in very rare cases.
sensitivity to stimulation, depression, other nervous signs) or vomiting. In cases of licking, the following may be observed:
On very rare occasions, a brief period of excessive salivation may occur, mainly due to the nature of the excipient.

The frequency of adverse reactions should be classified according to the following groups:
- Very frequently (more than 1 animal out of every 10 treated animals shows adverse reactions)
- Frequently (more than 1 but less than 10 animals per 100 animals treated)
- Infrequently (more than 1 but less than 10 animals per 1,000 animals treated)
- Rarely (more than 1 but less than 10 animals per 10,000 animals treated)
- Very rarely (less than 1 animal per 10,000 animals treated, including isolated cases).