L-Tryptophan

In dietary supplements such as L Tryptophan Now Foods or L Tryptophan Secom, the amino acid is available in the form of vegetable capsules or tablets, in concentrated forms, suitable for easy oral administration.

Vegetable capsules usually contain 500 mg of L-tryptophan, are free of animal-derived excipients, and are suitable for vegetarians and vegans.

The administration of L-tryptophan capsules is recommended in the following situations:

• Sleep disorders and insomnia – by increasing melatonin synthesis, it supports the regulation of the circadian rhythm.
• Depressive and anxiety disorders – due to its role as a serotonin precursor, it can help improve mood.
• Premenstrual syndrome (PMS) – it can reduce irritability, mood swings, and sugar cravings associated with the menstrual cycle.
• Support in quitting smoking or other addictions – contributes to emotional stability and impulse reduction.
• Reduction of migraines and tension headaches – effect observed in clinical studies.
• Support in cognitive decline – may have a neuroprotective effect and support cognitive function in the elderly.

The optimal dosage depends on the purpose of administration, concentration, and specialist recommendation.

• Swanson L Tryptophan: 1 capsule (500 mg) with water, 30-60 minutes before bedtime.
• Now Foods L Tryptophan: 1-2 capsules 2-3 times a day on an empty stomach, with the last dose before bedtime.

For effects on sleep, it is preferable to take it in the evening, and for mood regulation, the dose can be divided into several daily doses.

L-tryptophan supplements are contraindicated or require caution in:

• Pregnancy and breastfeeding – insufficient safety data.
• Allergy to any of the product's ingredients.
• Severe liver or kidney disorders – metabolism may be affected.

It is recommended to take on an empty stomach for optimal absorption.

Taking tryptophan supplements may cause drowsiness, so it is advisable to avoid driving or operating machinery after taking them.

Combining it with vitamin B6, magnesium, and niacin may increase the efficiency of conversion to serotonin.

Side effects are rare and usually mild, but may include:

• Excessive drowsiness
• Nausea, gastrointestinal disorders
• Dizziness
• Headache
• Rarely: allergic skin reactions

If you experience any unpleasant symptoms, consult your doctor or pharmacist.

L Tryptophan may interact with certain medications such as antidepressants (e.g., fluoxetine) – risk of excessive serotonin increase.

Caution is also advised when taking supplements containing 5-HTP or St. John's wort at the same time – cumulative serotonergic effect.

In the case of these drug interactions, there is a risk of serotonergic syndrome (manifested by agitation, hypertension, hyperthermia, tremor).

Acute overdose with L-tryptophan can lead to severe symptoms:

• Deep drowsiness
• Confusion
• Tachycardia
• Nausea, vomiting
• Signs of serotonin syndrome

Treatment consists of discontinuing administration and emergency medical assistance.

It is recommended to store this supplement at room temperature, away from moisture and direct light. Keep out of reach of children. Close the container tightly to prevent oxidation of the active substance. Observe the expiration date indicated on the package.

• PubMed, Analysis, nutrition, and health benefits of tryptophan
• WebMD, L-Tryptophan
• Healthline, What is tryptophan?
• MDPI, Tryptophan in Nutrition and Health