Anxin

Anxin PlantExtrakt is available in the form of vegetable capsules, packaged in boxes containing 20 capsules for oral administration. Each capsule contains:

• Standardised extract of Hypericum perforatum – 150 mg (minimum 0.45 mg hypericin);
• Passiflora incarnata extract – 70 mg;
• Camellia sinensis leaf extract – 30 mg;
• Excipients: microcrystalline cellulose, silica gel and magnesium stearate.

The pharmaceutical form ensures optimal bioavailability and controlled release of the active ingredients, maintaining a constant balance of the neurotransmitters involved in regulating mood.

Anxin capsules are recommended for:

• States of anxiety, nervousness and psychomotor agitation;
• Mild sleep disorders associated with stress;
• Irritability, mental tension and emotional fatigue;
• Difficulties concentrating caused by mental overload;
• Melancholy or mild mood disorders;
• Periods of difficult adjustment, such as major life changes, professional stress or exams.

Hypericum perforatum inhibits monoamine oxidase (MAO) enzymes and the reuptake of serotonin, dopamine and noradrenaline – key neurotransmitters involved in emotional balance – and has a natural antidepressant and anxiolytic effect.

Passiflora incarnata exerts a mild sedative effect by activating GABA receptors, reducing mental tension and promoting relaxation.

Camellia sinensis (green tea) has a tonic and antioxidant effect due to its L-theanine and polyphenol content, maintaining mental clarity and counteracting fatigue.

For adults and adolescents over 14 years of age, the recommended dose is 1 capsule twice a day, taken 30 minutes before meals with a glass of water.

It is important not to exceed the recommended daily dose, as excessive dosing does not enhance the therapeutic effects but may promote adverse reactions.

The use of Anxin is contraindicated in the following situations:

• Known hypersensitivity to any of the product's components;
• Pregnancy and breastfeeding, due to the lack of safety data and the possible hormonal action of St. John's wort extracts;
• Children under 14 years of age, in the absence of adequate clinical studies.

People with liver or neurological disorders or a history of severe depression should consult their doctor before starting treatment.

During administration, it is recommended to avoid prolonged exposure to sunlight or ultraviolet radiation, as St. John's wort can cause photosensitivity, manifested by skin reactions to light.

Concomitant administration with other supplements containing sedative herbs (valerian, melatonin, lavender) should be done with caution to avoid potentiating the hypnotic effect.

In general, Anxin is well tolerated. However, in rare cases, the following may occur:

• Allergic skin reactions (rash, itching, hives);
• Mild gastrointestinal disorders (nausea, abdominal pain);
• Headache or dizziness in sensitive individuals;
• Drowsiness or, conversely, mild mental agitation;
• Photosensitivity – redness or burning reactions after exposure to the sun.

Side effects usually disappear when administration is discontinued.

Anxin may interact with numerous medicines, particularly due to its Hypericum perforatum content. Significant interactions may occur with:

• Hormonal contraceptives
• Anticoagulants (e.g. warfarin)
• Immunosuppressants (e.g. cyclosporine, tacrolimus)
• Antidepressants
• Antiretrovirals 
• Theophylline, digoxin and antiepileptics

No severe cases of overdose with Anxin have been reported. However, excessive administration may cause:

• Agitation, confusion, marked drowsiness or gastrointestinal disorders;
• In isolated cases, marked photosensitivity.

Treatment is symptomatic, and administration should be discontinued immediately.

Anxin should be stored at temperatures below 25°C, in a dry place, away from light and moisture. Keep out of the reach and sight of children. Food supplements are not a substitute for a varied diet and a balanced lifestyle.

• PubMed, Hypericum perforatum: Traditional uses, clinical studies, and drug interactions
• WebMD, St. John's Wort
• PubMed, Passiflora incarnata in neuropsychiatric disorders — a systematic review
• Healthline, Camellia sinensis leaf extract: benefits, uses, and side effects