XanterNet

EYE GEL

Sterile, transparent, preservative-free ophthalmic gel containing sodium hyaluronate, xanthan gum and netilmicin 0.3%. Medical device indicated for the treatment of wounds and abrasions of the ocular surface caused by trauma or after surgery. Xanternet is particularly indicated for patients who, in the opinion of the physician, are at risk of infection.
It contains two natural polymers: hyaluronic acid and xanthan gum. Applied to the conjunctival fornix, Xanternet mixes with tears and forms a viscous, transparent dressing that reduces friction caused by eye movements and blinking, protecting the surface of the eye and promoting healing from wounds or abrasions.
Xanternet also contains netilmicin, a broad-spectrum aminoglycoside antibiotic useful for reducing the risk of bacterial infections.
The product does not contain preservatives.

Composition
Sodium hyaluronate; xanthan gum; netilmicin 0.3%; disodium phosphate dodecahydrate; monosodium phosphate monohydrate; sodium citrate; purified water.

How to use
It is recommended to administer Xanternet into the conjunctival fornix in a dose of one drop 4 times a day, unless the doctor indicates otherwise.
Instructions for use:
1. Before use, make sure the single-dose container is intact.
2. Peel the single dose off the foil.
3. Hold the base single-dose container and shake it downward.
4. Open by rotating the top and pulling.
5. Instill Xanternet avoiding the tip of the container coming into contact with the eye or any other surface.

Contraindications
Hypersensitivity to aminoglycosides or to any other component of the product.

Precautions for use
Prolonged use of topical antibiotics can lead to the development of resistant microorganisms.
If, after a reasonable period of time (5-7 days), the use of the Xanternet viscous bandage does not lead to an improvement in the clinical picture or if irritation or manifestations of hypersensitivity occur, treatment should be discontinued and a specialist should be consulted.
In early childhood, the product should only be administered when strictly necessary and under the direct supervision of a physician.

Interactions with other drugs or medical devices for ophthalmic use
No significant drug interactions have been reported with the ophthalmic use of Netilmicin. However, due to the physical properties of the gel, it is recommended that other ophthalmic medications or medical devices not be administered within 60 minutes of administering Xanternet.
Concomitant administration, even topically, especially intracavitary, of other potentially nephrotoxic and ototoxic antibiotics may increase the risk of such effects.
An increase in the potential nephrotoxicity of some aminoglycosides has been reported following subsequent or concomitant administration, which should be avoided, of other potentially nephrotoxic substances such as cisplatin, polymyxin B, colistin, viomycin, streptomycin, vancomycin, other aminoglycosides and some cephalosporins (cephaloridine) or potent diuretics such as ethacrynic acid and furosemide, due to repercussions on the kidneys.
In vitro, the combination of an aminoglycoside with a beta-lactam antibiotic (penicillin or cephalosporin) can cause significant mutual inactivation. Even when an aminoglycoside and a penicillin-like antibiotic were administered by two different routes, a reduction in the plasma half-life or plasma levels of the aminoglycoside was observed in patients with renal impairment and in some patients with normal renal function.

Other interactions
The product has been shown to be compatible with the simultaneous use of therapeutic contact lenses after PRK surgery.
The use of other types of contact lenses is not recommended if 60 minutes have not passed since applying Xanternet.

Pregnancy and breastfeeding
Preclinical studies confirm the absence of fetal toxicity with topical administration of Netilmicin, due to the low systemic absorption of the product. However, during pregnancy, it should be administered only when strictly necessary and under the direct supervision of a physician.
Aminoglycosides are excreted in breast milk, therefore their administration during breastfeeding is not recommended.

warnings
For topical ocular use only.
Keep out of reach of children.
The product should be used on the recommendation of a doctor.
Occasionally, mild, transient burning may occur.
Do not touch the end of the open container or bring it into direct contact with your eyes.
Each single-dose container should be used immediately after opening; any residue should not be reused.
Do not use Xanternet after the expiration date.
Do not use Xanternet if the container is open or damaged.
Don't use Xanternet if it's not transparent.
The administration of Xanternet to children or people with limited abilities must be carried out by a responsible adult.

Conservation
Because Xanternet does not contain preservatives, each single-dose container should only be used immediately after opening.
After opening the sachet, remaining single-dose vials should be used within 12 weeks.
Store below 30°C.

Format
Pack of 20 single-dose containers.

CE Marking Registration Number 0373

Code: HA/NET GEL