COMBOLINE® SPOT-ON DOG
External antiparasitic in topical solution
Pharmaceutical form
Spot-on solution (Sol.so.)

Composition per pipette:
- 0.67 ml pipette: Fipronil 67 mg; (S)-methoprene 60.30 mg; butylhydroxyanisole (E 320) 0.13 mg; butylhydroxytoluene (E 321) 0.07 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 1.34 ml pipette: Fipronil 134 mg; (S)-methoprene 120.6 mg; butylhydroxyanisole (E 320) 0.27 mg; butylhydroxytoluene (E 321) 0.13 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 2.68 ml pipette: Fipronil 268 mg; (S)-methoprene 241.2 mg; butylhydroxyanisole (E 320) 0.54 mg; butylhydroxytoluene (E 321) 0.27 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 4.02 ml pipette: Fipronil 402 mg; (S)-methoprene 361.8 mg; butylhydroxyanisole (E 320) 0.8 mg; butylhydroxytoluene (E 321) 0.4 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

Pharmacological properties
The product is a topical insecticidal, acaricidal solution containing a combination of an adulticidal active ingredient, fipronil, with an ovicidal and larvicidal active ingredient, (S)-methoprene.
Fipronil is an insecticide/acaricide that belongs to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels.
(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects.

Interactions and incompatibilities
None known.