Cresemba is used in adults to treat the following fungal infections:
- invasive aspergillosis, caused by a fungus from the "Aspergillus" group;
- mucormycosis, caused by a fungus from the "Mucorales" group in patients for whom treatment with amphotericin B is not appropriate.

Do not take Cresemba:
- if you are allergic to isavuconazole or any of the other ingredients of this medicine (listed in section 6).

Talk to your doctor, pharmacist or nurse before taking Cresemba.

Pregnancy and breastfeeding:
If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, ask your doctor for advice before using this medicine.
Do not use Cresemba if you are pregnant, unless your doctor tells you otherwise. This is recommended because it is not known whether it can harm or have any negative effects on the unborn baby.
Do not breast-feed if you are taking Cresemba.

Driving and using machines:
Cresemba may cause confusion, tiredness or drowsiness. It may also lead to loss of consciousness. Therefore, be very careful when driving or using machines.

Always take this medicine exactly as your doctor or pharmacist has told you.
Talk to your doctor or pharmacist if you are not sure.

Initial dose for the first two days (48 hours)
The recommended dose is two capsules taken every 8 hours.

Usual dose after the first two days
Its administration begins 12-24 hours after the last initial dose. The recommended dose is two capsules taken once a day.
You will take this dose until your doctor tells you otherwise. The duration of treatment with Cresemba may exceed 6 months if your doctor considers this necessary.

The capsules can be taken with or without food. Swallow the capsules whole. Do not chew, crush, dissolve or open the capsules.

-The active substance is isavuconazole. Each capsule contains 186.3 mg isavuconazonium sulfate, corresponding to a concentration of 100 mg isavuconazole.
- The other components are:
- Capsule contents: magnesium citrate (anhydrous), microcrystalline cellulose, talc, colloidal anhydrous silica, stearic acid.
- Capsule shell: hypromellose, water, red iron oxide (E172) (capsule body only), titanium dioxide (E171), gellan gum, potassium acetate, disodium edetate, sodium lauryl sulfate.
- Printing ink: shellac resin, propylene glycol, potassium hydroxide, black iron oxide (E172).

Warning:
Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

14 capsules