Manganese

Manganese can be administered in several pharmaceutical forms, each with specific absorption and bioavailability characteristics.

There is Natural Manganese capsules from DVR Pharm, each capsule containing dried and deactivated brewer's yeast with manganese extract. This formula ensures an optimal intake of the trace element and controlled release into the body.

Trace Minerals' liquid ionic manganese comes in the form of a solution containing 72 trace minerals in ionic form, sourced from the Great Salt Lake in Utah, USA. This facilitates rapid and efficient absorption of manganese.

This manganese supplement is recommended for a variety of conditions and deficiencies, including:

• Maintaining healthy bones and connective tissues
• Protecting cells against oxidative stress
• Supporting energy metabolism
• Improving cognitive function and reducing fatigue
• Optimal absorption of calcium and iron in the body.

The recommended dose varies depending on the pharmaceutical form and individual needs:

• Natural Manganese capsules: take 1 capsule per day, and in special cases, on the recommendation of a doctor, the dose may be increased to 2 capsules per day.
• Liquid manganese: 1.75 ml (approximately 1/3 teaspoon) administered over 2 days, mixed with a large glass of water or juice.

If you have a known manganese deficiency, your doctor will determine the dosage regimen appropriate for your needs.

Manganese is generally well tolerated and has no major contraindications. However, caution is advised in people with severe liver or kidney disease, as its elimination may be impaired.

Pregnant or breastfeeding women should also consult a doctor before taking it.

To maximise the benefits of manganese supplementation, the following measures are recommended:

• Take with food for optimal absorption.
• Avoid excessive consumption, as excessive intake may interfere with the absorption of other essential minerals.
• Follow the recommended daily dose to prevent toxic accumulation in the body.

Side effects are rare at recommended doses, but in case of excessive consumption, symptoms such as the following may occur:

• Gastrointestinal disorders (nausea, vomiting, diarrhoea);
• Neurological symptoms (tremor, difficulty concentrating);
• Mineral imbalances due to interference with the absorption of other trace elements.

Manganese may interact with certain drugs and micronutrients, influencing their absorption and metabolism:

• Antipsychotic drugs
• Antibiotics – manganese may reduce the effectiveness of certain antibiotics, such as tetracyclines and quinolones
• Zinc supplements – excessive manganese intake can reduce zinc absorption, affecting the body's mineral balance.

Although manganese toxicity is rare at usual doses, long-term excessive exposure can cause severe symptoms, including:

• Neurotoxicity, manifested by symptoms similar to Parkinson's disease
• Memory impairment and cognitive dysfunction
• Impaired liver and kidney function.

In case of overdose, discontinue use and consult a doctor immediately.

To maintain the stability and effectiveness of the product, manganese should be stored under appropriate conditions, at temperatures below 25°C, in a dry place away from light and out of the reach of children. Keep the product in its tightly closed packaging to prevent contamination.

• WebMD, Manganese
• The Nutrition Science, Manganese
• Healthline, 10 evidence-based benefits of manganese
• RxList, Manganese