Description

GRIPBLOCKER EXPRESS is a medication used for the short-term treatment of cold and flu symptoms. It relieves symptoms such as fever, nasal congestion, and dry cough.

Composition

The active substances of the drug are paracetamol (Paracetamolum) , pseudoephedrine hydrochloride (Pseudoephedrini hydrochloridum) , dextromethorphan hydrobromide (Dextromethorphani hydrobromidum) .

1 capsule contains 300 mg of paracetamol, 30 mg of pseudoephedrine hydrochloride and 12 mg of dextromethorphan hydrobromide.

Excipients: macrogol 400, glycerol, propylene glycol, povidone K17, purified water, gelatin, liquid non-crystallizing sorbitol, cochineal red E124.

Dosage

Always use this medicine exactly as described in this leaflet or as advised by your doctor or pharmacist.

The drug is administered orally.

• Adults and adolescents over 12 years of age: 1 to 2 capsules, 3-4 times daily. Do not take more than 8 capsules per day.
• Children 6 to 12 years of age: 1 capsule 3-4 times daily. Do not take more than 4 capsules per day.

If after 3 days of using the medicine there is no improvement or the patient feels worse, contact your doctor.

Action

The medicine contains three active substances: paracetamol, pseudoephedrine and dextromethorphan.
Paracetamol relieves pain and reduces fever. Pseudoephedrine clears nasal congestion by constricting blood vessels in the nose. Dextromethorphan relieves dry (non-productive) coughs.

Indications

GRIPBLOCKER EXPRESS is used for the temporary treatment of symptoms of colds, flu, flu-like conditions, and sinusitis, such as:

• fever,
• rhinitis,
• cough,
• headache,
• sore throat,
• muscle and bone-joint pain.

Contraindications

When not to use GRIPBLOCKER EXPRESS :

• if you are allergic to the active substances or any of the other ingredients of this medicine,
• if you are taking other medicines containing paracetamol,
• if you are taking monoamine oxidase inhibitors (MAOIs) or have taken these medicines within 2 weeks of stopping them,
• in patients with congenital glucose-6-phosphate dehydrogenase deficiency,
• in severe renal or hepatic failure,
• in severe hypertension,
• in ischemic heart disease,
• in alcoholism,
• in bronchial asthma,
• if you have hereditary constitutional hyperbilirubinemia (Gilbert's disease).

Side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects may occur when using GRIPBLOCKER EXPRESS :

Heart disorders:

• increased heart rate

Blood and lymphatic system disorders:

• granulocytopenia (reduction in the number of white blood cells - granulocytes in the blood),
• agranulocytosis (lack of granulocytes in the blood),
• thrombocytopenia (platelet deficiency).

Nervous system disorders;

• drowsiness, dizziness.

Gastrointestinal disorders:

• nausea, vomiting

Kidney and urinary tract disorders:

• renal colic, renal papillary necrosis, acute renal failure, urolithiasis, urinary disorders, urinary retention may occur, especially in patients with prostatic hyperplasia.

Skin and subcutaneous tissue disorders:

• allergic skin reactions, skin redness, rash.

Vascular disorders:

• slight increase in blood pressure,

General disorders and administration site conditions:

• tiredness,

Immune system disorders:

• Type I hypersensitivity reactions: allergic edema (swelling of the skin and soft tissues, often in the face, e.g. lips, tongue, eyelids), anaphylactic reaction (shortness of breath, bronchospasm, sweating, nausea, low blood pressure).

Respiratory, thoracic and mediastinal disorders:

• attack of bronchial asthma,

Hepatobiliary disorders:

• liver damage,

Mental disorders:

• hallucinations.

Warnings and precautions

• The drug should not be used in case of chronic cough with expectoration of sputum.
• Exercise particular caution in individuals with increased intraocular pressure, prostatic hyperplasia, hyperthyroidism, diabetes, and those taking anxiolytics, tricyclic antidepressants, other sympathomimetic drugs, i.e. decongestants, appetite suppressants and amphetamine-like psychostimulants, and anticoagulants.
• Long-term use of painkillers, especially in combination with different painkillers, may cause permanent kidney damage with the risk of kidney failure.
• Store in the original packaging at a temperature below 25°C.
• Keep the medicine out of the sight and reach of children.

Use of other medications

Tell your doctor or pharmacist about all the medicines you are taking, have recently taken or might take.

The interaction of GRIPBLOCKER EXPRESS with other drugs is due to the interaction of the active substances contained in the drug:

Paracetamol:

• Drugs that accelerate gastric emptying (e.g. metoclopramide) accelerate the absorption of paracetamol, while drugs that delay gastric emptying (e.g. propantheline) may delay the absorption of paracetamol.
• The use of paracetamol simultaneously with MAO inhibitors (used to treat depression, among others) and within 2 weeks after discontinuing treatment with these drugs may cause agitation and fever.
• Concomitant use of paracetamol with zidovudine (AZT, a drug used in HIV infection) may enhance the toxic effects of zidovudine on the bone marrow.
• Paracetamol may enhance the effect of anticoagulants (coumarin derivatives).
• Concomitant use of paracetamol and drugs that increase hepatic metabolism, i.e. some sleeping pills or antiepileptic drugs, e.g. phenobarbital, phenytoin, carbamazepine, as well as rifampicin (used in the treatment of tuberculosis, among others) may lead to liver damage, even when using the recommended doses of paracetamol.
• Drinking alcohol during paracetamol treatment leads to the formation of a toxic metabolite that causes liver cell necrosis, which may subsequently lead to liver failure.
• Co-administration of paracetamol with chloramphenicol (a broad-spectrum antibiotic) may result in increased plasma chloramphenicol concentrations.

Pseudoephedrine

• Concomitant use with albuterol (used, among others, to treat asthma) may intensify the vasoconstrictor effect.
• Do not use concomitantly with amitriptyline (used, among others, for depression) and sympathomimetics, i.e. decongestants.
• Concomitant use with other sympathomimetics (used, among others, to treat bronchospasm, e.g. asthma), appetite suppressants and amphetamine-like psychostimulants may cause an increase in blood pressure.
• Ammonium chloride, by alkalizing urine, increases the reabsorption of pseudoephedrine metabolites in the kidneys and prolongs its duration of action.
• Antacids (used to relieve heartburn and indigestion) may increase the absorption of pseudoephedrine.
• MAO inhibitors (used to treat depression) slow down the elimination of pseudoephedrine from the body and increase its bioavailability.
• Pseudoephedrine reduces the effect of antihypertensive drugs and may modify the effect of digitalis glycosides (used in heart failure).
• Do not use concomitantly with furazolidine (an antibacterial drug).

Dextromethorphan

• Do not use with MAO inhibitors (used to treat depression).
• Alcohol may increase the adverse effects of dextromethorphan.

Taking the medicine with food and drink

Food does not significantly alter the absorption of the drug.
You must not drink alcohol while taking the medicine.

Pregnancy and breastfeeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

The use of GRIPBLOCKER EXPRESS during pregnancy and breastfeeding is contraindicated.

Use of the drug in children and adolescents

The medicine should not be used in children under 6 years of age.

Driving and operating machinery

GRIPBLOCKER EXPRESS may impair your ability to drive or operate machinery.